- Teshaev Shukhrat Jumayevich
Doctor of Medical Sciences, Professor of the Department of Anatomy, Clinical Anatomy and Operative Surgery with Topographic Anatomy at the Bukhara State Medical Institute named after Abu Ali ibn Sino. Bukhara, Uzbekistan
teshayev@bsmi.uz https://orcid.org/0009-0002-1996-4275 - odirov Oybek O‘ktam o‘g‘li
Department of Gistology, Sitology Va Embryology, Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Republic of Uzbekistan.
oybek_qodirov@bsmi.uz https://orcid.org/0009-0000-1723-4303 - Davlatov Salim Sulaymonovich
DSc, professor of the Department of Faculty and Hospital Surgery urology. Bukhara State Medical Institute named after Abu Ali ibn Sino Bukhara, Uzbekistan.
pro.ilmiy@bsmi.uz https://orcid.org/0000-0002-3268-7156 - Kosim Rakhmanov Erdanovich
Doctor of Medical Sciences, Professor, Head of the Department of Surgery, Endoscopy, and Anesthesiology-Reanimatology, Faculty of Postgraduate Education, Samarkand State Medical University Samarkand, Republic of Uzbekistan.
qosimraxmanov@sammu.uz https://оrсid.оrg/0000-0002-3898-504 - Hamroyev Izzat Sayfilloyevich
Republican Scientific Center for Emergency Medical Care, Bukhara Branch, Uzbekistan.
izzathamroyev@gmail.com https://оrсid.оrg/0000-0002-3898-509 - Rajabova Nargiza Khazratkulovna
Base doctoral student of the Department of Anatomy and Clinical Anatomy (OXTA), Bukhara State Medical Institute named after Abu Ali ibn Sino Bukhara, Uzbekistan.
nrajabova074@gmail.com https://orcid.org/0000-0002-3268-7156
Volume 11 - No: 2
Morphometric and Histological Alterations in the Spleen Induced by Chronic Carbon Monoxide Exposure and the Corrective Effects of Gulimaxsar
DOI: 10.28978/nesciences.262009
Keywords: Oxidative stress, apoptosis, spleen, morphological changes, experimental study.
Abstract
Chronic exposure to carbon monoxide (CO) induces hypoxia and is associated with structural and functional alterations in the spleen. This study aimed to evaluate morphometric and histological changes splenic tissue under prolonged CO exposure and to assess the corrective effects of the medicinal plant Gulimaxsar. Results showed a significant decrease in white pulp area (−33.3%), germinal center diameter (−28.3%), and marginal zone thickness (−34.0%) (p < 0.05), along with an increase in red pulp sinusoid diameter (+47.9%), indicating vascular congestion and immunosuppression. Administration of Gulimaxsar extract resulted in partial restoration of splenic structure, including an increase in white pulp area (+33.8%) and germinal center diameter (+27.6%) (p < 0.05), and a reduction in sinusoidal dilation. These findings indicate that Gulimaxsar exerts protective effects against CO-induced splenic damage, likely due to its antioxidant and antihypoxic properties.