- Teshaev Ulugbek Shukhratovich
Assistant of the Department of Faculty and Hospital Surgery, PhD. Bukhara State Medical Institute named after Abu Ali ibn Sino. Bukhara, Uzbekistan.
https://orcid.org/0009-0000-0052-2827 - Aripova Tamara Uktamovna
Director of the Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan
https://orcid.org/0009-0009-3342-8760 - Teshaev Shukhrat Jumayevich
Doctor of Medical Sciences, Professor of the Department of Anatomy, Clinical Anatomy and Operative Surgery with Topographic Anatomy at the Bukhara State Medical Institute named after Abu Ali ibn Sino. Bukhara, Uzbekistan.
https://orcid.org/0009-0002-1996-4275 - Yarbekov Rustam Raimkulovich
Doctor of Medical Sciences, Head of the Department of Ischemic Heart Disease Republican Specialized Scientific and Practical Medical Center of Surgery named after Academician V. Vakhidov, Tashkent, Uzbekistan
https://orcid.org/0000-0001-5918-8181 - Khamdamov Bakhtiyor Zarifovich
Head of the Department of Faculty and Hospital Surgery and Urology. Doctor of Medical Sciences, Professor. Abu Ali ibn Sino Bukhara State Medical Institute. Bukhara, Uzbekistan.
https://orcid.org/0000-0003-1799-3777 - Rukhsora Uktamova
Lecturer, Department of Internal Medicine in Family Medicine, Bukhara State Medical Institute,
https://orcid.org/0009-0001-7195-5125
Volume 11 - No: 3
Development and Validation of an Immunoinflammatory Biomarker Model for Predicting Postoperative Inflammatory Responses: A Molecular and Biochemical Approach
DOI: 10.28978/nesciences.263009
Keywords: Coronary artery bypass grafting (CABG); Non-infectious postoperative complications; Immunoinflammatory profile; Immunogenetic biomarkers; Prognostic model; Systemic inflammatory response; Endothelial activation; Risk stratification.
Abstract
Non-infectious postoperative complications remain a major cause of morbidity after coronary artery bypass grafting (CABG), contributing to prolonged hospitalization, delayed recovery, increased healthcare costs, and unfavorable cardiovascular outcomes. Current risk stratification systems, including EuroSCORE II and the Society of Thoracic Surgeons (STS) Risk Calculator, are primarily based on clinical and operative variables and therefore do not adequately reflect the marked interindividual variability of the perioperative immune-inflammatory response. Increasing evidence indicates that dysregulated inflammatory and endothelial activation plays a central role in the pathogenesis of postoperative complications; however, reliable prognostic models integrating these biological mechanisms remain limited. This study was therefore designed to develop and validate an immunoinflammatory prognostic model capable of improving early prediction of non-infectious postoperative complications following CABG.